![]() (A) Sodium dodecyl sulphate-polyacrylamide gel electrophoresis showing purity of His-tagged RBD of spike protein (lane 1) and His-tagged NP (lane 3). No genome mutations were detected on serial samples. Anti-SARS-CoV-2-NP or anti-SARS-CoV-2-RBD IgG levels correlated with virus neutralisation titre ( R 2>0♹). ![]() ![]() For 16 patients with serum samples available 14 days or longer after symptom onset, rates of seropositivity were 94% for anti-NP IgG (n=15), 88% for anti-NP IgM (n=14), 100% for anti-RBD IgG (n=16), and 94% for anti-RBD IgM (n=15). Older age was correlated with higher viral load (Spearman's ρ=0♴8, 95% CI 0♰74–0♷5 p=0♰20). In one patient, viral RNA was detected 25 days after symptom onset. Salivary viral load was highest during the first week after symptom onset and subsequently declined with time (slope −0♱5, 95% CI −0♱9 to −0♱1 R 2=0♷1). The median viral load in posterior oropharyngeal saliva or other respiratory specimens at presentation was 5♲ log 10 copies per mL (IQR 4♱–7♰).
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |